““The Effect of Particle Size on the Physical Characteristics and Drug-release Behavior of Mini-tablets” was selected by the editorial board of Trends in Sciences.

Authors: Awis Sukarni Mohmad Sabere and Mohd Muzamir Mahat 

Abstract: This study aimed to investigate the influence of particle size of the excipients on the behavior of mini-tablets in terms of physical characteristics and drug release profiles. Material and methods: All of the mini-tablets based on HPMC, PEG 6K and PEO 8M PVP produced high quality mini-tablets from both sieve fractions while 90F was very fragile. Results: Crushing strength values were the most pronounced difference between the mini-tablets from all formulations. The PEO 8M-based mini-tablets showed the highest values and deformation behavior instead of fracture. Water absorption and drug release profiles also showed intriguing and different results between the various formulations. Conclusion: The results suggested that even though different particle size has limited effect on the physical characteristic of the product, it may have a significant effect on its drug dissolution profile. 

Trends in Sciences, 18(21), 43. https://doi.org/10.48048/tis.2021.43